Anti-NOTUM Monoclonal Antibody (4C5)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC430	Anti-NOTUM Antibody (4C5)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC430-P	Anti-NOTUM Antibody (4C5), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC430-A	Anti-NOTUM Antibody (4C5), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC430-H	Anti-NOTUM Antibody (4C5), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC430-B	Anti-NOTUM Antibody (4C5), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC430

Anti-NOTUM Antibody (4C5)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC430-P

Anti-NOTUM Antibody (4C5), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC430-A

Anti-NOTUM Antibody (4C5), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC430-H

Anti-NOTUM Antibody (4C5), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC430-B

Anti-NOTUM Antibody (4C5), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-NOTUM Monoclonal Antibody (4C5)
- Product Description:
  
  The Anti-NOTUM antibody is a human monoclonal antibody recommended for use in functional assay, inhibition and other applications. This antibody specifically targets NOTUM and demonstrates reactivity with human.
  
  Applications:
  
  Functional Assay, Inhibition
  
  Target:
  
  NOTUM
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Notum (Notum pectinacetylesterase).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  4C5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NOTUM Monoclonal Antibody (4C5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

NOTUM

Protein Name

Palmitoleoyl-protein carboxylesterase NOTUM

Introduction

The NOTUM protein is an intriguing component in the Wnt signaling pathway, playing an important role in development and disease. It is an enzyme known as a serine hydrolase, and it functions as a lysophospholipase involved in the regulation of Wnt signaling, which is a key pathway in regulating cellular processes such as growth, differentiation, and cell fate determination.

Alternative Names

NOTUM; Palmitoleoyl-protein carboxylesterase NOTUM

Gene ID

147111

UniProt

Q6P988

Subcellular Location

Secreted

Tissue Specificity

Rarely expressed in adult normal tissues.

Cell Line Specificity

Cancer enhanced

Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

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