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Anti-NOTCH4 Monoclonal Antibody (GLA-S4F18)
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Product Description:This antibody GLA-S4F18 specifically binds to the negative regulatory region (NRR) of Notch 4. Notch 4 is a member of the Notch family of receptors involved in cell differentiation, proliferation, and apoptotic processes.Applications:Enzyme-Linked Immunosorbent AssaySource:HumanTarget:NOTCH4Specificity:Human and mouse notch 4Clonality:MonoclonalClone ID:GLA-S4F18Isotype:Human IgG1, LambdaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NOTCH4 Monoclonal Antibody (GLA-S4F18) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
NOTCH4
Protein Name
Neurogenic locus notch homolog protein 4
Introduction
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Alternative Names
Notch 4; INT3; Neurogenic Locus Notch Homolog Protein 4; Notch (Drosophila) Homolog 4; Notch Homolog 4 (Drosophila); Notch Homolog 4; HNotch4
Gene ID
UniProt
Tissue Specificity
Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
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