Anti-NOTCH2 Monoclonal Antibody (B6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC848	Anti-NOTCH2 Antibody (B6)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC848-P	Anti-NOTCH2 Antibody (B6), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC848-A	Anti-NOTCH2 Antibody (B6), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC848-H	Anti-NOTCH2 Antibody (B6), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC848-B	Anti-NOTCH2 Antibody (B6), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Anti-NOTCH2 Monoclonal Antibody (B6)
- Product Description:
  
  The Anti-NOTCH2 antibody is a mouse monoclonal antibody recommended for use in inhibition, blocking, ELISA and other applications. This antibody specifically targets NOTCH2 and demonstrates reactivity with human, mouse.
  
  Applications:
  
  Inhibition, Blocking, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  NOTCH2
  
  Target Species:
  
  Mouse
  
  Specificity:
  
  This antibody reacts with Mouse mNRR2 and human hNRR2.
  
  Immunogen:
  
  Mouse Notch Receptor 2
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  B6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NOTCH2 Monoclonal Antibody (B6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

NOTCH2

Protein Name

Neurogenic locus notch homolog protein 2

Introduction

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Alternative Names

Notch 2; HN2; hN2; AGS2; HJCYS

Gene ID

4853

UniProt

Q04721

Related Disease

Alagille syndrome 2 (ALGS2)

Subcellular Location

[Notch 2 extracellular truncation]: Cell membrane

Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Cell Line Specificity

Low cancer specificity

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.

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