Anti-NOTCH1 Monoclonal Antibody (9G5)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC429	Anti-NOTCH1 Antibody (9G5)	Human IgG1	None	$460	In stock	Add
ASPC429-P	Anti-NOTCH1 Antibody (9G5), PE	Human IgG1	PE	$1,180	2-3 weeks	Add
ASPC429-A	Anti-NOTCH1 Antibody (9G5), APC	Human IgG1	APC	$980	2-3 weeks	Add
ASPC429-H	Anti-NOTCH1 Antibody (9G5), HRP	Human IgG1	HRP	$600	2-3 weeks	Add
ASPC429-B	Anti-NOTCH1 Antibody (9G5), Biotin	Human IgG1	Biotin	$680	2-3 weeks	Add

Anti-NOTCH1 Monoclonal Antibody (9G5)
- Product Description:
  
  The Anti-NOTCH1 antibody is a human monoclonal antibody recommended for use in functional assay, inhibition and other applications. This antibody specifically targets NOTCH1 and demonstrates reactivity with human.
  
  Applications:
  
  Functional Assay, Inhibition
  
  Target:
  
  NOTCH1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Notch1 (Notch homolog 1).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  9G5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NOTCH1 Monoclonal Antibody (9G5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

NOTCH1

Protein Name

Neurogenic locus notch homolog protein 1

Introduction

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Alternative Names

Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1, Translocation-Associated (Drosophila); Notch Homolog 1, Translocation-Associated

Gene ID

4851

UniProt

P46531

Molecule Mass

Postsynaptic proteins

Related Disease

Aortic valve disease 1 (AOVD1)

Subcellular Location

Cell membrane

Tissue Specificity

In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

Cell Line Specificity

Low cancer specificity

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.

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