-
Anti-NOTCH1 Monoclonal Antibody (23814)
-
Product Description:23814 is a monoclonal antibody that reacts with the Notch1 protein in human. This antibody has cross-reactivity with mouse Notch1 protein.Applications:Surface Plasmon Resonance, Functional Assay, Blocking, Flow CytometrySource:HumanTarget:NOTCH1Specificity:Human and mouse notch 1 proteinClonality:MonoclonalClone ID:23814Isotype:Human IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
-
-
Anti-NOTCH1 Monoclonal Antibody (23814) Applications
-
Note:Optimal dilutions/concentrations should be determined by the end user.
-
Gene Symbol
NOTCH1
Protein Name
Neurogenic locus notch homolog protein 1
Molecular Family
Postsynaptic proteins
Introduction
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Alternative Names
Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1, Translocation-Associated (Drosophila); Notch Homolog 1, Translocation-Associated
Gene ID
UniProt
Subcellular Location
Nucleoplasm
Tissue Specificity
In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Cell Type
Thymocytes
Customer Reviews
There are no reviews for Product Name.
Submit a review and receive an Amazon gift card.
Publications
There are no publications for Product Name.
If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward
