Anti-NCOA3 Monoclonal Antibody (B-15A5)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C1314	Anti-NCOA3 Antibody (B-15A5)	Mouse IgG2b, Kappa		None		$460		Add

Anti-NCOA3 Monoclonal Antibody (B-15A5)
- Product Description:
  
  The Anti-NCOA3 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human and pig NCOA3.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  NCOA3
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Nuclear Receptor Coactivator 3 (NCOA3).
  
  Immunogen:
  
  Recombinant NCOA3 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  B-15A5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.05% Proclin 300
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NCOA3 Monoclonal Antibody (B-15A5) Applications
- Recommended Dilution:
  
  Western Blot: 0.5-2 µg/mL
  Immunohistochemistry: 5-20 µg/mL
  Immunocytochemistry: 5-20 µg/mL
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Nuclear receptor coactivator 3

Introduction

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Alternative Names

ACTR; AIB-1; AIB1; CAGH16; CTG26; KAT13B; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; bHLHe42; pCIP

Gene ID

8202

UniProt

Q9Y6Q9

Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Cell Line Specificity

Low cancer specificity

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

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