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Anti-MYOZ2 Monoclonal Antibody (D-15F3)
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Product Description:The Anti-MYOZ2 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human MYOZ2.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:MYOZ2Target Species:HumanSpecificity:This antibody reacts with human Myozenin 2 (MYOZ2).Clonality:MonoclonalClone ID:D-15F3Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-MYOZ2 Monoclonal Antibody (D-15F3) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Myozenin-2
Introduction
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder.
Alternative Names
C4orf5; CMH16; CS-1
Gene ID
UniProt
Related Disease
Cardiomyopathy, familial hypertrophic, 16 (CMH16)
Subcellular Location
Cytoplasm, myofibril, sarcomere, Z line
Tissue Specificity
Expressed specifically in heart and skeletal muscle.
Cell Line Specificity
Cancer enhanced
Function
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
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