Anti-MUC16 Monoclonal Antibody (VK8)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC302	Anti-MUC16 Antibody (VK8)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC302-P	Anti-MUC16 Antibody (VK8), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC302-A	Anti-MUC16 Antibody (VK8), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC302-H	Anti-MUC16 Antibody (VK8), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC302-B	Anti-MUC16 Antibody (VK8), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Anti-MUC16 Monoclonal Antibody (VK8)
- Product Description:
  
  The Anti-MUC16 antibody is a mouse monoclonal antibody recommended for use in immunofluorescence, flow cytometry and other applications. This antibody specifically targets MUC16 and demonstrates reactivity with human.
  
  Applications:
  
  Immunofluorescence, Flow Cytometry, Western Blot
  
  Target:
  
  MUC16
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human MUC16.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  VK8
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MUC16 Monoclonal Antibody (VK8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MUC16

Protein Name

Mucin-16

Introduction

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

Alternative Names

MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125

Gene ID

94025

UniProt

Q8WXI7

Tissue Specificity

Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.

Cell Line Specificity

Cancer enhanced

Function

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

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