Anti-MUC1 Monoclonal Antibody (14F10)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC437	Anti-MUC1 Antibody (14F10)	Human IgG1, Lambda		None	$460	4-6 weeks	Add
ASPC437-1	Anti-MUC1 Antibody (14F10), scFv fragment	Human scFv	His tag	None	$460	In stock	Add
ASPC437-P	Anti-MUC1 Antibody (14F10), PE	Human IgG1, Lambda		PE	$1,180	4-6 weeks	Add
ASPC437-A	Anti-MUC1 Antibody (14F10), APC	Human IgG1, Lambda		APC	$980	4-6 weeks	Add
ASPC437-H	Anti-MUC1 Antibody (14F10), HRP	Human IgG1, Lambda		HRP	$600	4-6 weeks	Add
ASPC437-B	Anti-MUC1 Antibody (14F10), Biotin	Human IgG1, Lambda		Biotin	$680	4-6 weeks	Add

Anti-MUC1 Monoclonal Antibody (14F10)
- Product Description:
  
  The Anti-MUC1 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets MUC1 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  MUC1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human MUC1 (Mucin 1).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  14F10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MUC1 Monoclonal Antibody (14F10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MUC1

Protein Name

Mucin-1

Introduction

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Alternative Names

Mucin 1, Cell Surface Associated; Tumor-Associated Epithelial Membrane Antigen; Breast Carcinoma-Associated Antigen DF3; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Carcinoma-Associated Mucin; Mucin 1, Transmembrane; Krebs Von Den Lungen-6; Cancer Antigen 15-3; Episialin; CA 15-3; H23AG; MUC-1; KL-6; PEMT; EMA; PUM; PEM

Gene ID

4582

UniProt

P15941

Molecule Mass

CD Molecules

Subcellular Location

Apical cell membrane

Cell Line Specificity

Cancer enhanced

Function

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

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