Anti-MUC1 Monoclonal Antibody (12D10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC101	Anti-MUC1 Antibody (12D10)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC101-P	Anti-MUC1 Antibody (12D10), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC101-A	Anti-MUC1 Antibody (12D10), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC101-H	Anti-MUC1 Antibody (12D10), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC101-B	Anti-MUC1 Antibody (12D10), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Anti-MUC1 Monoclonal Antibody (12D10)
- Product Description:
  
  12D10 is a monoclonal antibody that specifically recognizes and binds to the MUC1 protein. MUC1 (Mucin 1) is a glycoprotein expressed on the surface of epithelial cells and has important roles in cell adhesion, signaling, and protection.
  
  Applications:
  
  Surface Plasmon Resonance, Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Source:
  
  Mouse
  
  Target:
  
  MUC1
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human MUC1
  
  Immunogen:
  
  Human MUC1 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12D10
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MUC1 Monoclonal Antibody (12D10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MUC1

Protein Name

Mucin-1

Molecular Family

CD Molecules

Introduction

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Alternative Names

Mucin 1, Cell Surface Associated; Tumor-Associated Epithelial Membrane Antigen; Breast Carcinoma-Associated Antigen DF3; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Carcinoma-Associated Mucin; Mucin 1, Transmembrane; Krebs Von Den Lungen-6; Cancer Antigen 15-3; Episialin; CA 15-3; H23AG; MUC-1; KL-6; PEMT; EMA; PUM; PEM;

Gene ID

4582

UniProt

P15941

Related Disease

Tubulointerstitial kidney disease, autosomal dominant, 2 (ADTKD2)

Subcellular Location

Plasma membrane

Tissue Specificity

Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.

Cell Type

Dendritic cells, Epithelial cells, T cells

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