Anti-MPL Monoclonal Antibody (4A1)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC409	Anti-MPL Antibody (4A1)	Mouse IgG2b, Kappa	None	$460	In stock	Add
ASPC409-P	Anti-MPL Antibody (4A1), PE	Mouse IgG2b, Kappa	PE	$1,180	2-3 weeks	Add
ASPC409-A	Anti-MPL Antibody (4A1), APC	Mouse IgG2b, Kappa	APC	$980	2-3 weeks	Add
ASPC409-H	Anti-MPL Antibody (4A1), HRP	Mouse IgG2b, Kappa	HRP	$600	2-3 weeks	Add
ASPC409-B	Anti-MPL Antibody (4A1), Biotin	Mouse IgG2b, Kappa	Biotin	$680	2-3 weeks	Add

Anti-MPL Monoclonal Antibody (4A1)
- Product Description:
  
  The Anti-MPL antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets MPL and demonstrates reactivity with human and cynomolgus monkey.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  MPL
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human TPOR (Thrombopoietin receptor).
  
  Immunogen:
  
  Human MPL protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  4A1
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MPL Monoclonal Antibody (4A1) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MPL

Protein Name

Thrombopoietin receptor

Introduction

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Alternative Names

MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; TPOR; C-MPL; CD110; THCYT2

Gene ID

4352

UniProt

P40238

Molecule Mass

CD Molecules

Related Disease

Amegakaryocytic thrombocytopenia, congenital, 1 (CAMT1)

Subcellular Location

Cell membrane

Tissue Specificity

Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.

Cell Line Specificity

Cancer enriched

Function

Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation.

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