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Anti-Mouse PDGFRB Monoclonal Antibody (3H6)
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Product Description:The Anti-PDGFRB antibody is a human monoclonal antibody recommended for use in flow cytometry, western blot, neutralization and other applications. This antibody specifically targets PDGFRB and demonstrates reactivity with mouse.Applications:Flow Cytometry, Western Blot, NeutralizationTarget:PDGFRBSpecificity:This antibody reacts with PDGFRB.Clonality:MonoclonalClone ID:3H6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-Mouse PDGFRB Monoclonal Antibody (3H6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
Pdgfrb
Protein Name
Platelet-derived growth factor receptor beta
Introduction
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.
Alternative Names
IMF1; KOGS; IBGC4; JTK12; OPDKD; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1
Gene ID
UniProt
Molecule Mass
CD Molecules, Cytokine/Chemokine Receptors
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
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