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Anti-Mouse CD38 Monoclonal Antibody (NIMR-5)
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Product Description:The Anti-CD38 antibody is a mouse monoclonal antibody recommended for use in neutralization, flow cytometry, immunohistochemistry - Frozen, immunoprecipitation and other applications. This antibody specifically targets CD38 and demonstrates reactivity with mouse.Applications:Enzyme-Linked Immunosorbent Assay, Neutralization, Flow Cytometry, Immunohistochemistry - Frozen, ImmunoprecipitationTarget:CD38Specificity:This antibody reacts with Mouse CD38.Clonality:MonoclonalClone ID:NIMR-5Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-Mouse CD38 Monoclonal Antibody (NIMR-5) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD38
Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Introduction
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia.
Alternative Names
CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase
Gene ID
UniProt
Subcellular Location
Membrane
Function
Synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP), the former a second messenger for glucose-induced insulin secretion, the latter a Ca(2+) mobilizer. Also has cADPR hydrolase activity (By similarity).
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