Anti-MMP13 Monoclonal Antibody (13F3)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC286	Anti-MMP13 Antibody (13F3)	Human IgG1	None	$460	4-6 weeks	Add
ASPC286-P	Anti-MMP13 Antibody (13F3), PE	Human IgG1	PE	$1,180	4-6 weeks	Add
ASPC286-A	Anti-MMP13 Antibody (13F3), APC	Human IgG1	APC	$980	4-6 weeks	Add
ASPC286-H	Anti-MMP13 Antibody (13F3), HRP	Human IgG1	HRP	$600	4-6 weeks	Add
ASPC286-B	Anti-MMP13 Antibody (13F3), Biotin	Human IgG1	Biotin	$680	4-6 weeks	Add

Anti-MMP13 Monoclonal Antibody (13F3)
- Product Description:
  
  The Anti-MMP13 antibody is a human monoclonal antibody recommended for use in ELISA, immunohistochemistry and other applications. This antibody specifically targets MMP13 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Immunohistochemistry
  
  Target:
  
  MMP13
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human MMP-13 (Matrix Metalloproteinases 13).
  
  Immunogen:
  
  Human MMP13 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  13F3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MMP13 Monoclonal Antibody (13F3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MMP13

Protein Name

Collagenase 3

Introduction

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia.

Alternative Names

MMP13; matrix metallopeptidase 13; CLG3; MDST; MANDP1; MMP-13

Gene ID

4322

UniProt

P45452

Related Disease

Spondyloepimetaphyseal dysplasia, Missouri type (SEMDM)

Subcellular Location

Secreted, extracellular space, extracellular matrix

Cell Line Specificity

Cancer enhanced

Function

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

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