Anti-MET Monoclonal Antibody (1H8)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC603	Anti-MET Antibody (1H8)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC603-P	Anti-MET Antibody (1H8), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC603-A	Anti-MET Antibody (1H8), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC603-H	Anti-MET Antibody (1H8), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC603-B	Anti-MET Antibody (1H8), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-MET Monoclonal Antibody (1H8)
- Product Description:
  
  The Anti-MET antibody is a human monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets MET and demonstrates reactivity with human, mouse.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  MET
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human HGFR.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1H8
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MET Monoclonal Antibody (1H8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MET

Protein Name

Hepatocyte growth factor receptor

Introduction

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXCs.

Alternative Names

MET; met proto-oncogene (hepatocyte growth factor receptor); hepatocyte growth factor receptor; HGFR; RCCP2

Gene ID

4233

UniProt

P08581

Molecule Mass

Protein Kinases/Phosphatase

Subcellular Location

Membrane; Single-pass type I membrane protein. [Isoform 3]: Secreted.

Cell Line Specificity

Cancer enhanced

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).

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