Anti-MEF2C Monoclonal Antibody (ASPR061)

Subcat	Description	Isotype	Conjugate	Price
ASPR61	Anti-MEF2C Antibody (ASPR061)	Mouse IgG1, Kappa	None	$530	Add
ASPR61-A	Anti-MEF2C Antibody (ASPR061), APC	Mouse IgG1, Kappa	APC	$1,030	Add
ASPR61-B	Anti-MEF2C Antibody (ASPR061), Biotin	Mouse IgG1, Kappa	Biotin	$760	Add
ASPR61-H	Anti-MEF2C Antibody (ASPR061), HRP	Mouse IgG1, Kappa	HRP	$680	Add
ASPR61-P	Anti-MEF2C Antibody (ASPR061), PE	Mouse IgG1, Kappa	PE	$1,280	Add

Anti-MEF2C Monoclonal Antibody (ASPR061)
- Product Description:
  
  The anti-MEF2C antibody is a mouse monoclonal antibody recommended for Surface Plasmon Resonance, Western Blot, Enzyme-Linked Immunosorbent Assay, Immunofluorescence. This antibody specifically targets MEF2C and demonstrates reactivity with human.
  
  Applications:
  
  Surface Plasmon Resonance, Western Blot, Enzyme-Linked Immunosorbent Assay, Immunofluorescence
  
  Target:
  
  MEF2C
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human MEF2C.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MEF2C Monoclonal Antibody (ASPR061) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MEF2C

Protein Name

Myocyte-Specific Enhancer Factor 2C

Introduction

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

Alternative Names

MEF2C; DEL5q14.3; Myocyte Enhancer Factor 2C; MADS Box Transcription Enhancer Factor 2, Polypeptide C; Myocyte-Specific Enhancer Factor 2C

Gene ID

4208

UniProt

Q06413

Related Disease

Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (NEDHSIL)

Subcellular Location

Cytoplasm
Nucleus

Tissue Specificity

Expressed in brain and skeletal muscle.

Function

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).
Isoforms that lack the repressor domain are more active than isoform 1.

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