Anti-MBP Monoclonal Antibody (F28C4)

Subcat	Description	Isotype	Conjugate	Price
ASPC1250	Anti-MBP Antibody (F28C4)	Mouse IgG2a, Lambda	None	$460	Add
ASPC1250-A	Anti-MBP Antibody (F28C4), APC	Mouse IgG2a, Lambda	APC	$980	Add
ASPC1250-B	Anti-MBP Antibody (F28C4), Biotin	Mouse IgG2a, Lambda	Biotin	$680	Add
ASPC1250-H	Anti-MBP Antibody (F28C4), HRP	Mouse IgG2a, Lambda	HRP	$600	Add
ASPC1250-P	Anti-MBP Antibody (F28C4), PE	Mouse IgG2a, Lambda	PE	$1,180	Add

Anti-MBP Monoclonal Antibody (F28C4)
- Product Description:
  
  The Anti-MBP antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay and other applications. This antibody specifically targets MBP and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  MBP
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human MBP.
  
  Immunogen:
  
  Acetylated residues 1-9 of Myelin Basic Protein (MBP).
  
  Epitope:
  
  ASQKRPSQR
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  F28C4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MBP Monoclonal Antibody (F28C4) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MBP

Protein Name

Myelin basic protein

Introduction

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Alternative Names

MBP; Myelin basic protein; Myelin A1 protein

Gene ID

4155

UniProt

P02686

Subcellular Location

Myelin membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Cell Line Specificity

Cancer enriched

Function

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

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