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Anti-MBP Monoclonal Antibody (B5V6)
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Product Description:This antibody binds to aa 130-156 of human MBP. It's validated in ELISA. Azide-free with low endotoxin, it is suitable for MS biomarker assays and CNS injury models.Applications:Enzyme-linked Immunosorbent AssaySource:HumanTarget:MBPTarget Species:HumanSpecificity:This antibody reacts with Human MBP.Epitope:AA 130-156Clonality:MonoclonalClone ID:B5V6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-MBP Monoclonal Antibody (B5V6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
MBP
Protein Name
Myelin Basic Protein
Introduction
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Alternative Names
Myelin Basic Protein; Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Golli-MBP
Gene ID
UniProt
Related Disease
Multiple Sclerosis
Subcellular Location
Cell membrane, Membrane, Nucleus
Tissue Specificity
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Cell Line Specificity
Cancer enriched
Function
Myelin Basic Protein, a key component of the myelin sheath in the nervous system.
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