Anti-MBP Monoclonal Antibody (845D3)

Subcat	Description	Isotype	Conjugate	Price
ASPF27	Anti-MBP Antibody (845D3)	Mouse IgG1	None	$460	Add
ASPF27-A	Anti-MBP Antibody (845D3), APC	Mouse IgG1	APC	$980	Add
ASPF27-B	Anti-MBP Antibody (845D3), Biotin	Mouse IgG1	Biotin	$680	Add
ASPF27-H	Anti-MBP Antibody (845D3), HRP	Mouse IgG1	HRP	$600	Add
ASPF27-P	Anti-MBP Antibody (845D3), PE	Mouse IgG1	PE	$1,180	Add

Anti-MBP Monoclonal Antibody (845D3)
- Product Description:
  
  This mouse IgG is specific for the human myelin basic protein epitope aa 80-89. With >95% purity and an azide-free format, it is a key reagent used to quantify MBP in CSF or tissue lysates and to study demyelinating diseases like multiple sclerosis. It's validated in RIA and ELISA.
  
  Applications:
  
  Radioimmunoassay, Enzyme-linked Immunosorbent Assay
  
  Source:
  
  Mouse
  
  Target:
  
  MBP
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human MBP.
  
  Immunogen:
  
  The human MBP peptide comprising amino acids from 80-89.
  
  Epitope:
  
  AA 80-89
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  845D3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-MBP Monoclonal Antibody (845D3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

MBP

Protein Name

Myelin Basic Protein

Introduction

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Alternative Names

Myelin Basic Protein; Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Golli-MBP

Gene ID

4155

UniProt

P02686

Related Disease

Multiple Sclerosis

Subcellular Location

Cell membrane, Membrane, Nucleus

Tissue Specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Cell Line Specificity

Cancer enriched

Function

Myelin Basic Protein, a key component of the myelin sheath in the nervous system.

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