Anti-MAPT Monoclonal Antibody (MN423)

Anti-MAPT Monoclonal Antibody (MN423)

Cat No: ASPC086

Summary
Host Species:
Mouse
Species Reactivity:
Human
Applications:
Immunocytochemistry, Enzyme-Linked Immunosorbent Assay, Western Blot, Immunofluorescence, Immunohistochemistry
Clone ID:
MN423
Clonality:
Monoclonal

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Product Information
Subcat Description Isotype Antibody Modification Conjugate Size Price Availability Quantity
ASPC086 Anti-MAPT Antibody (MN423) Mouse IgG2b, Kappa None $460 In stock
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ASPC086-P Anti-MAPT Antibody (MN423), PE Mouse IgG2b, Kappa PE $1,180 2-3 weeks
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ASPC086-A Anti-MAPT Antibody (MN423), APC Mouse IgG2b, Kappa APC $980 2-3 weeks
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ASPC086-H Anti-MAPT Antibody (MN423), HRP Mouse IgG2b, Kappa HRP $600 2-3 weeks
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ASPC086-B Anti-MAPT Antibody (MN423), Biotin Mouse IgG2b, Kappa Biotin $680 2-3 weeks
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ASPC086-4 Anti-MAPT Antibody (MN423), Fc Silenced Mouse IgG2b, Kappa Fc Silenced None $980 4-6 weeks
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Custom Antibody We can also offer conjugation antibodies (Alexa Fluor, Cy, APC, etc.) and other format antibodies (low endotoxin, Fab, scFv, etc.)

  • Anti-MAPT Monoclonal Antibody (MN423)
    • Product Description:
      MN423 specifically recognizes tau protein subunits that are associated with the core structure of paired helical filaments (PHFs) in AD.
      Applications:
      Immunocytochemistry, Enzyme-Linked Immunosorbent Assay, Western Blot, Immunofluorescence, Immunohistochemistry
      Source:
      Mouse
      Target:
      MAPT
      Target Species:
      Human
      Specificity:
      Tau Protein (Core PHF Subunits)
      Immunogen:
      Paired helical filaments (PHF) core
      Clonality:
      Monoclonal
      Clone ID:
      MN423
      Isotype:
      Mouse IgG2b, Kappa
      Purification:
      The antibody was purified by Protein A.
      Purity:
      >95% as determined by SDS-PAGE
      Aggregation:
      <5% as determined by SEC
      Concentration:
      1 mg/mL
      Form:
      Liquid
      Endotoxin:
      Please contact us for more information.
      Formulation:
      Contact us for customized product form or formulation.
      Preservative:
      BSA and Azide free.
      Stabilizer:
      None
      Shipping:
      Shipped at 4°C.
      Storage:
      This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
  • Anti-MAPT Monoclonal Antibody (MN423) Applications
    • Note:
      Optimal dilutions/concentrations should be determined by the end user.
Gene Symbol
MAPT
Protein Name
Microtubule-associated protein tau
Molecular Family
Tau
Introduction
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Alternative Names
Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU
Gene ID
UniProt
Related Disease
Frontotemporal dementia (FTD)
Subcellular Location
Nuclear speckles,Plasma membrane
Tissue Specificity
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
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