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Anti-MAPT Monoclonal Antibody
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Product Description:The Anti-MAPT antibody is a chicken monoclonal antibody recommended for use in immunohistochemistry, enzyme-linked immunosorbent assay, surface plasmon resonance and other applications. This antibody specifically targets MAPT and demonstrates reactivity with human.Applications:Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Surface Plasmon ResonanceTarget:MAPTTarget Species:HumanSpecificity:This antibody reacts with Human MAPT.Clonality:MonoclonalPurification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-MAPT Monoclonal Antibody Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
MAPT
Protein Name
Microtubule-associated protein tau
Introduction
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Alternative Names
Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU
Gene ID
UniProt
Related Disease
Alzheimer disease
Subcellular Location
Cytoplasm, cytosol
Tissue Specificity
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Cell Line Specificity
Group enriched
Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity.
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