Anti-LILRB4 Monoclonal Antibody (12F10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC424	Anti-LILRB4 Antibody (12F10)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC424-P	Anti-LILRB4 Antibody (12F10), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC424-A	Anti-LILRB4 Antibody (12F10), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC424-H	Anti-LILRB4 Antibody (12F10), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC424-B	Anti-LILRB4 Antibody (12F10), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-LILRB4 Monoclonal Antibody (12F10)
- Product Description:
  
  The Anti-LILRB4 antibody is a human monoclonal antibody recommended for use in blocking, ELISA, flow cytometry, inhibition and other applications. This antibody specifically targets LILRB4 and demonstrates reactivity with human.
  
  Applications:
  
  Blocking, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Inhibition, Western Blot
  
  Target:
  
  LILRB4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human LILRB4.
  
  Immunogen:
  
  Human LILRB4 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12F10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-LILRB4 Monoclonal Antibody (12F10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

LILRB4

Protein Name

Leukocyte immunoglobulin-like receptor subfamily B member 4

Introduction

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names

LILRB4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; ILT3; LIR5; CD85K; ILT-3; LIR-5; leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5

Gene ID

11006

UniProt

Q8NHJ6

Molecule Mass

CD Molecules

Subcellular Location

Cell membrane

Tissue Specificity

Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.

Cell Line Specificity

Cancer enriched

Function

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance.

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