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Anti-LGR5 Monoclonal Antibody (13B5)
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Product Description:The Anti-LGR5 antibody is a mouse monoclonal antibody recommended for use in western blot, ELISA, flow cytometry, immunohistochemistry and other applications. This antibody specifically targets LGR5 and demonstrates reactivity with human.Applications:Western Blot, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, ImmunohistochemistryTarget:LGR5Target Species:HumanSpecificity:This antibody reacts with human LGR5.Immunogen:Recombinant Human LGR5 proteinClonality:MonoclonalClone ID:13B5Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-LGR5 Monoclonal Antibody (13B5) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
LGR5
Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 5
Introduction
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
Alternative Names
FEX; HG38; GPR49; GPR67; GRP49
Gene ID
UniProt
Cell Line Specificity
Cancer enhanced
Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
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