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Anti-LGALS1 Monoclonal Antibody (SAIC-25B-112)
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Product Description:The Anti-LGALS1 antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets LGALS1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western blotTarget:LGALS1Target Species:HumanSpecificity:This antibody reacts with Human LGALS1.Immunogen:KLH-coupled peptide from Galectin 1.Clonality:MonoclonalClone ID:SAIC-25B-112Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-LGALS1 Monoclonal Antibody (SAIC-25B-112) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
LGALS1
Protein Name
Galectin-1
Introduction
Lectin, Galactoside-Binding, Soluble, 1 (Galectin-1) is a carbohydrate-binding protein (lectin) that binds to beta-galactosides. It is involved in a wide range of biological processes, including cell growth, differentiation, apoptosis, and immune regulation through its interactions with cell surface glycoconjugates.
Alternative Names
GAL1; GBP
Gene ID
UniProt
Subcellular Location
Secreted, extracellular space, extracellular matrix
Tissue Specificity
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
Cell Line Specificity
Low cancer specificity
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69.
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