Anti-LDLR Monoclonal Antibody (12G4)

Subcat	Description	Isotype	Conjugate	Price
ASPC1234	Anti-LDLR Antibody (12G4)	Mouse IgG1, Kappa	None	$460	Add
ASPC1234-A	Anti-LDLR Antibody (12G4), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1234-B	Anti-LDLR Antibody (12G4), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1234-H	Anti-LDLR Antibody (12G4), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1234-P	Anti-LDLR Antibody (12G4), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1234

Anti-LDLR Antibody (12G4)

Mouse IgG1, Kappa

None

$460

Add

ASPC1234-A

Anti-LDLR Antibody (12G4), APC

Mouse IgG1, Kappa

APC

$980

Add

ASPC1234-B

Anti-LDLR Antibody (12G4), Biotin

Mouse IgG1, Kappa

Biotin

$680

Add

ASPC1234-H

Anti-LDLR Antibody (12G4), HRP

Mouse IgG1, Kappa

HRP

$600

Add

ASPC1234-P

Anti-LDLR Antibody (12G4), PE

Mouse IgG1, Kappa

$1,180

Add

Anti-LDLR Monoclonal Antibody (12G4)
- Product Description:
  
  The Anti-LDLR antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, enzyme-linked immunosorbent assay, blocking and other applications. This antibody specifically targets LDLR and demonstrates reactivity with Hamster, Rat, Human, Mouse.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Blocking
  
  Source:
  
  Mouse
  
  Target:
  
  LDLR
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with LDLR.
  
  Immunogen:
  
  Human LDLR
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12G4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-LDLR Monoclonal Antibody (12G4) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

LDLR

Protein Name

Low-density lipoprotein receptor

Introduction

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Alternative Names

FH; FHC; LDLCQ2

Gene ID

3949

UniProt

P01130

Subcellular Location

Cell membrane

Cell Line Specificity

Low cancer specificity

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021).

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