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Anti-L1CAM Monoclonal Antibody (15F7)
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Product Description:The Anti-L1CAM antibody is a mouse monoclonal antibody recommended for use in western blot, immunohistochemistry, ELISA, flow cytometry and other applications. This antibody specifically targets L1CAM and demonstrates reactivity with human.Applications:Western Blot, Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Flow CytometryTarget:L1CAMTarget Species:HumanSpecificity:This antibody reacts with human L1CAM.Clonality:MonoclonalClone ID:15F7Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-L1CAM Monoclonal Antibody (15F7) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
L1CAM
Protein Name
Neural cell adhesion molecule L1
Introduction
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Alternative Names
L1CAM; L1 cell adhesion molecule; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
Gene ID
UniProt
Molecule Mass
Adhesion Molecules
Related Disease
Hydrocephalus, congenital, X-linked (HYCX)
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enhanced
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
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