Anti-KRT17 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1233	Anti-KRT17 Antibody	Human IgG1, Kappa	None	$460	Add
ASPC1233-A	Anti-KRT17 Antibody, APC	Human IgG1, Kappa	APC	$980	Add
ASPC1233-B	Anti-KRT17 Antibody, Biotin	Human IgG1, Kappa	Biotin	$680	Add
ASPC1233-H	Anti-KRT17 Antibody, HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC1233-P	Anti-KRT17 Antibody, PE	Human IgG1, Kappa	PE	$1,180	Add

Anti-KRT17 Monoclonal Antibody
- Product Description:
  
  The Anti-KRT17 antibody is a human monoclonal antibody recommended for use in flow cytometry, enzyme-linked immunosorbent assay and other applications. This antibody specifically targets KRT17 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Enzyme-Linked Immunosorbent Assay
  
  Source:
  
  Human
  
  Target:
  
  KRT17
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human KRT17.
  
  Immunogen:
  
  Human cytokeratin 17 protein.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-KRT17 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

KRT17

Protein Name

Keratin, type I cytoskeletal 17

Introduction

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.

Alternative Names

39.1; CK-17; K17; PC; PC2; PCHC1

Gene ID

3872

UniProt

Q04695

Subcellular Location

Cytoplasm

Tissue Specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

Cell Line Specificity

Cancer enhanced

Function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

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