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Anti-KL Monoclonal Antibody (13C8)
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Product Description:The Anti-KL antibody is a human monoclonal antibody recommended for use in western blot, flow cytometry, functional assay and other applications. This antibody specifically targets KL and demonstrates reactivity with human.Applications:Western Blot, Flow Cytometry, Functional AssayTarget:KLTarget Species:HumanSpecificity:This antibody reacts with human klotho.Clonality:MonoclonalClone ID:13C8Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-KL Monoclonal Antibody (13C8) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
KL
Protein Name
Klotho
Introduction
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Alternative Names
KL; klotho
Gene ID
UniProt
Related Disease
Tumoral calcinosis, hyperphosphatemic, familial, 3 (HFTC3)
Subcellular Location
[Isoform 1]: Cell membrane
Tissue Specificity
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
Cell Line Specificity
Cancer enhanced
Function
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
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