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Anti-KIR2DL3 Monoclonal Antibody (11F11)
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Product Description:The Anti-KIR2DL3 antibody is a human monoclonal antibody recommended for use in ELISA, western blot, Radioimmunoassay, neutralization and other applications. This antibody specifically targets KIR2DL3 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western Blot, Radioimmunoassay, NeutralizationTarget:KIR2DL3Target Species:HumanSpecificity:This antibody reacts with human KIR2DL3.Clonality:MonoclonalClone ID:11F11Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-KIR2DL3 Monoclonal Antibody (11F11) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
KIR2DL3
Protein Name
Killer cell immunoglobulin-like receptor 2DL3
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alternative Names
p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS3; KIR2DS5; KIRCL23; KIR-023GB
Gene ID
UniProt
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Function
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
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