Anti-JCV VP1 Monoclonal Antibody (5G3)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC706	Anti-JCV VP1 Antibody (5G3)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC706-P	Anti-JCV VP1 Antibody (5G3), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC706-A	Anti-JCV VP1 Antibody (5G3), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC706-H	Anti-JCV VP1 Antibody (5G3), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC706-B	Anti-JCV VP1 Antibody (5G3), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC706

Anti-JCV VP1 Antibody (5G3)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC706-P

Anti-JCV VP1 Antibody (5G3), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC706-A

Anti-JCV VP1 Antibody (5G3), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC706-H

Anti-JCV VP1 Antibody (5G3), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC706-B

Anti-JCV VP1 Antibody (5G3), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-JCV VP1 Monoclonal Antibody (5G3)
- Product Description:
  
  The Anti-JCV VP1 antibody is a human monoclonal antibody recommended for use in ELISA, immunofluorescence, dot blot, flow cytometry, neutralization, immunohistochemistry, western blot and other applications. This antibody specifically targets JCV VP1.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Dot Blot, Flow Cytometry, Neutralization, Immunohistochemistry, Western Blot
  
  Target:
  
  JCV VP1
  
  Specificity:
  
  This antibody reacts with JC Virus.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  5G3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-JCV VP1 Monoclonal Antibody (5G3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Major capsid protein VP1

Introduction

Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with a N-linked glycoprotein containing terminal alpha2-6-linked sialic acids on the cell surface to provide virion attachment to target cell. The serotonergic receptor 5HT2AR also acts as a cellular receptor for JCV on human glial cells. Once attached, the virions enter predominantly by a ligand-inducible clathrin-dependent pathway and traffic to the ER. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.

Alternative Names

Major capsid protein VP1; JCV VP1

UniProt

P03089

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