Anti-ITGAE Monoclonal Antibody (8A11)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC440	Anti-ITGAE Antibody (8A11)	Human IgM, Kappa		None	$460	4-6 weeks	Add
ASPC440-1	Anti-ITGAE Antibody (8A11), Fab fragment	Human Fab	His tag	None	$460	In stock	Add
ASPC440-P	Anti-ITGAE Antibody (8A11), PE	Human IgM, Kappa		PE	$1,180	4-6 weeks	Add
ASPC440-A	Anti-ITGAE Antibody (8A11), APC	Human IgM, Kappa		APC	$980	4-6 weeks	Add
ASPC440-H	Anti-ITGAE Antibody (8A11), HRP	Human IgM, Kappa		HRP	$600	4-6 weeks	Add
ASPC440-B	Anti-ITGAE Antibody (8A11), Biotin	Human IgM, Kappa		Biotin	$680	4-6 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC440

Anti-ITGAE Antibody (8A11)

Human IgM, Kappa

None

$460

4-6 weeks

Add

ASPC440-1

Anti-ITGAE Antibody (8A11), Fab fragment

Human Fab

His tag

None

$460

In stock

Add

ASPC440-P

Anti-ITGAE Antibody (8A11), PE

Human IgM, Kappa

$1,180

4-6 weeks

Add

ASPC440-A

Anti-ITGAE Antibody (8A11), APC

Human IgM, Kappa

APC

$980

4-6 weeks

Add

ASPC440-H

Anti-ITGAE Antibody (8A11), HRP

Human IgM, Kappa

HRP

$600

4-6 weeks

Add

ASPC440-B

Anti-ITGAE Antibody (8A11), Biotin

Human IgM, Kappa

Biotin

$680

4-6 weeks

Add

Anti-ITGAE Monoclonal Antibody (8A11)
- Product Description:
  
  The Anti-ITGAE antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets human ITGAE.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  ITGAE
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human AlphaE integrin (integrin αE chain).
  
  Immunogen:
  
  Human αEβ7 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  8A11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ITGAE Monoclonal Antibody (8A11) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ITGAE

Protein Name

Integrin alpha-E

Introduction

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

Alternative Names

ITGAE; integrin; alpha E (antigen CD103; human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103

Gene ID

3682

UniProt

P38570

Molecule Mass

Adhesion Molecules, CD Molecules

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Cell Line Specificity

Group enriched

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

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