Anti-ITGA4 Monoclonal Antibody (Natalizumab)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC036	Anti-ITGA4 Antibody (Natalizumab)	Human IgG4, Kappa	None	$460	4-6 weeks	Add
ASPC036-P	Anti-ITGA4 Antibody (Natalizumab), PE	Human IgG4, Kappa	PE	$1,180	2-3 weeks	Add
ASPC036-A	Anti-ITGA4 Antibody (Natalizumab), APC	Human IgG4, Kappa	APC	$980	2-3 weeks	Add
ASPC036-H	Anti-ITGA4 Antibody (Natalizumab), HRP	Human IgG4, Kappa	HRP	$600	2-3 weeks	Add
ASPC036-B	Anti-ITGA4 Antibody (Natalizumab), Biotin	Human IgG4, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC036

Anti-ITGA4 Antibody (Natalizumab)

Human IgG4, Kappa

None

$460

4-6 weeks

Add

ASPC036-P

Anti-ITGA4 Antibody (Natalizumab), PE

Human IgG4, Kappa

$1,180

2-3 weeks

Add

ASPC036-A

Anti-ITGA4 Antibody (Natalizumab), APC

Human IgG4, Kappa

APC

$980

2-3 weeks

Add

ASPC036-H

Anti-ITGA4 Antibody (Natalizumab), HRP

Human IgG4, Kappa

HRP

$600

2-3 weeks

Add

ASPC036-B

Anti-ITGA4 Antibody (Natalizumab), Biotin

Human IgG4, Kappa

Biotin

$680

2-3 weeks

Add

Anti-ITGA4 Monoclonal Antibody (Natalizumab)
- Product Description:
  
  Natalizumab is a humanized monoclonal antibody that targets the alpha-4 (α4) subunit of integrins, specifically α4β1 and α4β7 integrins. These integrins are cell adhesion molecules found on the surface of leukocytes, which are cells involved in the immune response.
  
  Applications:
  
  Blocking, Flow Cytometry
  
  Target:
  
  ITGA4
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human Integrin alpha 4/CD49D
  
  Immunogen:
  
  The RAMOS cell line
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Natalizumab
  
  Isotype:
  
  Human IgG4, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ITGA4 Monoclonal Antibody (Natalizumab) Applications
- Recommended Dilution:
  
  FCM 1:10
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ITGA4

Protein Name

Integrin alpha-4

Molecular Family

Adhesion Molecules, CD Molecules

Introduction

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.

Alternative Names

Integrin Subunit Alpha 4; IA4; CD49D

Gene ID

3676

UniProt

P13612

Subcellular Location

Plasma membrane

Cell Type

Fibroblasts

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