Anti-ITGA2B Monoclonal Antibody (10E5)

Subcat	Description	Isotype	Conjugate	Price
ASPC1216	Anti-ITGA2B Antibody (10E5)	Mouse IgG1, Kappa	None	$460	Add
ASPC1216-A	Anti-ITGA2B Antibody (10E5), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1216-B	Anti-ITGA2B Antibody (10E5), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1216-H	Anti-ITGA2B Antibody (10E5), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1216-P	Anti-ITGA2B Antibody (10E5), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1216

Anti-ITGA2B Antibody (10E5)

Mouse IgG1, Kappa

None

$460

Add

ASPC1216-A

Anti-ITGA2B Antibody (10E5), APC

Mouse IgG1, Kappa

APC

$980

Add

ASPC1216-B

Anti-ITGA2B Antibody (10E5), Biotin

Mouse IgG1, Kappa

Biotin

$680

Add

ASPC1216-H

Anti-ITGA2B Antibody (10E5), HRP

Mouse IgG1, Kappa

HRP

$600

Add

ASPC1216-P

Anti-ITGA2B Antibody (10E5), PE

Mouse IgG1, Kappa

$1,180

Add

Anti-ITGA2B Monoclonal Antibody (10E5)
- Product Description:
  
  The Anti-ITGA2B antibody is a mouse monoclonal antibody recommended for use in immunofluorescence, enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets ITGA2B and demonstrates reactivity with human.
  
  Applications:
  
  Immunofluorescence, Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  ITGA2B
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human ITGA2B.
  
  Immunogen:
  
  Platelets from human blood.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10E5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ITGA2B Monoclonal Antibody (10E5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ITGA2B

Protein Name

Integrin alpha-IIb

Introduction

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.

Alternative Names

BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93

Gene ID

3674

UniProt

P08514

Subcellular Location

Membrane

Cell Line Specificity

Cancer enriched

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity).

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