Anti-Integrin αIIbβ3 Monoclonal Antibody (314.3)

Subcat	Description	Isotype	Conjugate	Price
ASPC1222	Anti-Integrin αIIbβ3 Antibody (314.3)	Mouse IgG1, Kappa	None	$460	Add
ASPC1222-A	Anti-Integrin αIIbβ3 Antibody (314.3), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1222-B	Anti-Integrin αIIbβ3 Antibody (314.3), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1222-H	Anti-Integrin αIIbβ3 Antibody (314.3), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1222-P	Anti-Integrin αIIbβ3 Antibody (314.3), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1222

Anti-Integrin αIIbβ3 Antibody (314.3)

Mouse IgG1, Kappa

None

$460

Add

ASPC1222-A

Anti-Integrin αIIbβ3 Antibody (314.3), APC

Mouse IgG1, Kappa

APC

$980

Add

ASPC1222-B

Anti-Integrin αIIbβ3 Antibody (314.3), Biotin

Mouse IgG1, Kappa

Biotin

$680

Add

ASPC1222-H

Anti-Integrin αIIbβ3 Antibody (314.3), HRP

Mouse IgG1, Kappa

HRP

$600

Add

ASPC1222-P

Anti-Integrin αIIbβ3 Antibody (314.3), PE

Mouse IgG1, Kappa

$1,180

Add

Anti-Integrin αIIbβ3 Monoclonal Antibody (314.3)
- Product Description:
  
  The Anti-Integrin αIIbβ3 antibody is a mouse monoclonal antibody recommended for use in flow cytometry, functional assay and other applications. This antibody specifically targets Integrin αIIbβ3 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Functional Assay
  
  Target:
  
  Integrin αIIbβ3
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human Integrin αIIbβ3.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  314.3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-Integrin αIIbβ3 Monoclonal Antibody (314.3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ITGB3

Protein Name

Integrin beta-3

Introduction

Integrin αIIbβ3, also known as glycoprotein IIb/IIIa complex, is an important integrin receptor found on the surface of platelets. This integrin plays a critical role in hemostasis and thrombosis, which are processes related to blood clotting and wound healing.

Alternative Names

Integrin αIIbβ3; Integrin alpha 2b beta 3

Gene ID

3690

UniProt

P05106

Subcellular Location

Cell membrane

Tissue Specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Cell Line Specificity

Cancer enhanced

Function

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

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