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Anti-IL6ST Monoclonal Antibody (13F2)
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Product Description:The Anti-IL6ST antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry, western blot, functional assay and other applications. This antibody specifically targets IL6ST and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Western Blot, Functional AssayTarget:IL6STTarget Species:HumanSpecificity:This antibody reacts with human IL6ST.Clonality:MonoclonalClone ID:13F2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL6ST Monoclonal Antibody (13F2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL6ST
Protein Name
Interleukin-6 receptor subunit beta
Introduction
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
Alternative Names
IL6ST; interleukin 6 signal transducer; CD130; GP130; CDW130; IL-6RB
Gene ID
UniProt
Molecule Mass
CD Molecules
Related Disease
Hyper-IgE syndrome 4A, autosomal dominant, with recurrent infections (HIES4A)
Subcellular Location
[Isoform 1]: Cell membrane
Cell Line Specificity
Low cancer specificity
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