Anti-IL6R Monoclonal Antibody (Tocilizumab)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC040	Anti-IL6R Antibody (Tocilizumab)	Human IgG1, Kappa		None	$460	In stock	Add
ASPC040-P	Anti-IL6R Antibody (Tocilizumab), PE	Human IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC040-A	Anti-IL6R Antibody (Tocilizumab), APC	Human IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC040-H	Anti-IL6R Antibody (Tocilizumab), HRP	Human IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC040-B	Anti-IL6R Antibody (Tocilizumab), Biotin	Human IgG1, Kappa		Biotin	$680	2-3 weeks	Add
ASPC040-4	Anti-IL6R Antibody (Tocilizumab), Fc Silenced	Human IgG1, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC040

Anti-IL6R Antibody (Tocilizumab)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC040-P

Anti-IL6R Antibody (Tocilizumab), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC040-A

Anti-IL6R Antibody (Tocilizumab), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC040-H

Anti-IL6R Antibody (Tocilizumab), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC040-B

Anti-IL6R Antibody (Tocilizumab), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

ASPC040-4

Anti-IL6R Antibody (Tocilizumab), Fc Silenced

Human IgG1, Kappa

Fc Silenced

None

$980

4-6 weeks

Add

Anti-IL6R Monoclonal Antibody (Tocilizumab)
- Product Description:
  
  Tocilizumab is a monoclonal antibody that targets the interleukin-6 receptor (IL-6R). It blocks IL-6 from binding to its receptor (both membrane-bound and soluble forms), inhibiting the IL-6 mediated signal transduction that leads to inflammatory responses.
  
  Applications:
  
  Inhibition, Enzyme-Linked Immunosorbent Assay, Functional Assays
  
  Target:
  
  IL6R
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human IL6R
  
  Immunogen:
  
  Human IL6R protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Tocilizumab
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL6R Monoclonal Antibody (Tocilizumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL6R

Protein Name

Interleukin-6 receptor subunit alpha

Molecular Family

CD Molecules, Cytokine/Chemokine Receptors

Introduction

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

Alternative Names

Interleukin 6 Receptor

Gene ID

3570

UniProt

P08887

Related Disease

Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5)

Tissue Specificity

[Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820).

Cell Type

Lymphocytes, NK cells, NKT cells, T cells

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