Anti-IL6 Monoclonal Antibody (9H1)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC435	Anti-IL6 Antibody (9H1)	Human IgG1		None	$460	4-6 weeks	Add
ASPC435-1	Anti-IL6 Antibody (9H1), scFv fragment	Human scFv	His tag	None	$460	In stock	Add
ASPC435-P	Anti-IL6 Antibody (9H1), PE	Human IgG1		PE	$1,180	4-6 weeks	Add
ASPC435-A	Anti-IL6 Antibody (9H1), APC	Human IgG1		APC	$980	4-6 weeks	Add
ASPC435-H	Anti-IL6 Antibody (9H1), HRP	Human IgG1		HRP	$600	4-6 weeks	Add
ASPC435-B	Anti-IL6 Antibody (9H1), Biotin	Human IgG1		Biotin	$680	4-6 weeks	Add

Anti-IL6 Monoclonal Antibody (9H1)
- Product Description:
  
  The Anti-IL6 antibody is a human monoclonal antibody recommended for use in ELISA and other applications. This antibody specifically targets IL6 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  IL6
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human IL-6 (Interleukin 6).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  9H1
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL6 Monoclonal Antibody (9H1) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL6

Protein Name

Interleukin-6

Introduction

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Alternative Names

IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor

Gene ID

3569

UniProt

P05231

Molecule Mass

Cytokines

Related Disease

Rheumatoid arthritis systemic juvenile (RASJ)

Subcellular Location

Secreted

Tissue Specificity

Produced by skeletal muscle.

Cell Line Specificity

Cancer enhanced

Function

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).

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