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Anti-IL3RA Monoclonal Antibody (14A3)
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Product Description:The Anti-IL3RA antibody is a human monoclonal antibody recommended for use in functional assay and other applications. This antibody specifically targets IL3RA and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Functional AssayTarget:IL3RATarget Species:HumanSpecificity:This antibody reacts with human IL3RA.Clonality:MonoclonalClone ID:14A3Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL3RA Monoclonal Antibody (14A3) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL3RA
Protein Name
Interleukin-3 receptor subunit alpha
Introduction
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.
Alternative Names
Interleukin 3 Receptor Subunit Alpha; IL3RA
Gene ID
UniProt
Molecule Mass
CD Molecules, Cytokine/Chemokine Receptors
Subcellular Location
Membrane; Single-pass type I membrane protein.
Cell Line Specificity
Cancer enhanced
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).
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