Anti-IL34 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price
ASPC1535	Anti-IL34 Antibody	Human IgG1, Kappa		None	$530	Add
ASPC1535-A	Anti-IL34 Antibody, APC	Human IgG1, Kappa		APC	$1,030	Add
ASPC1535-B	Anti-IL34 Antibody, Biotin	Human IgG1, Kappa		Biotin	$760	Add
ASPC1535-H	Anti-IL34 Antibody, HRP	Human IgG1, Kappa		HRP	$680	Add
ASPC1535-P	Anti-IL34 Antibody, PE	Human IgG1, Kappa		PE	$1,280	Add
ASPC1535-4	Anti-IL34 Antibody, Fc Silenced	Human IgG1, Kappa	Fc Silenced	None	$980	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1535

Anti-IL34 Antibody

Human IgG1, Kappa

None

$530

Add

ASPC1535-A

Anti-IL34 Antibody, APC

Human IgG1, Kappa

APC

$1,030

Add

ASPC1535-B

Anti-IL34 Antibody, Biotin

Human IgG1, Kappa

Biotin

$760

Add

ASPC1535-H

Anti-IL34 Antibody, HRP

Human IgG1, Kappa

HRP

$680

Add

ASPC1535-P

Anti-IL34 Antibody, PE

Human IgG1, Kappa

$1,280

Add

ASPC1535-4

Anti-IL34 Antibody, Fc Silenced

Human IgG1, Kappa

Fc Silenced

None

$980

Add

Anti-IL34 Monoclonal Antibody
- Product Description:
  
  The Anti-IL34 antibody is a human monoclonal antibody recommended for neutralization, blocking and other applications. This antibody specifically targets IL34 and demonstrates reactivity with human and mouse.
  
  Applications:
  
  Neutralization, Blocking
  
  Source:
  
  Human
  
  Target:
  
  IL34
  
  Specificity:
  
  This antibody reacts with human and mouse IL34.
  
  Immunogen:
  
  IL34
  
  Clonality:
  
  Monoclonal
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL34 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL34

Protein Name

Interleukin-34

Introduction

IL-34 is a cytokine involved in the regulation of immune responses. It plays a role in the differentiation, survival, and function of myeloid cells by binding to its primary receptor, colony-stimulating factor-1 receptor (CSF-1R). IL-34 has been associated with various physiological and pathological processes, including inflammation, immune regulation, and development of antigen-presenting cells, and is studied in the context of autoimmune diseases and cancer.

Alternative Names

C16orf77; IL-34

Gene ID

146433

UniProt

Q6ZMJ4

Subcellular Location

Secreted

Tissue Specificity

Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Cell Line Specificity

Low cancer specificity

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

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