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Anti-IL21R Monoclonal Antibody (ATR-107)
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Product Description:The ATR-107 monoclonal antibody recognizes and binds to the extracellular domain of human, mouse, rat, and cynomolgus monkey IL-21R.Applications:Neutralization, Functional AssaySource:HumanTarget:IL21RSpecificity:Human and mouse IL21R extracellular domainsClonality:MonoclonalClone ID:ATR-107Isotype:Human IgG1, LambdaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL21R Monoclonal Antibody (ATR-107) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL21R
Protein Name
Interleukin-21 receptor
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Introduction
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Alternative Names
Interleukin 21 Receptor; IL21R
Gene ID
UniProt
Related Disease
Immunodeficiency 56 (IMD56)
Subcellular Location
Plasma membrane,Cytosol
Tissue Specificity
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Cell Type
B cells, NK cells, T cells, Tregs
Function
This is a receptor for interleukin-21.
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