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Anti-IL21 Monoclonal Antibody (13B11)
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Product Description:The Anti-IL21 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets IL21 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Western BlotTarget:IL21Target Species:HumanSpecificity:This antibody reacts with human IL-21 (Interleukin 21).Clonality:MonoclonalClone ID:13B11Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL21 Monoclonal Antibody (13B11) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL21
Protein Name
Interleukin-21
Introduction
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alternative Names
IL21; interleukin 21; Za11; IL-21; CVID11; interleukin-21; interleukin-21 isoform
Gene ID
UniProt
Molecule Mass
Cytokines
Related Disease
Immunodeficiency, common variable, 11 (CVID11)
Subcellular Location
Secreted
Tissue Specificity
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity).
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