Anti-IL1RAP Monoclonal Antibody (11H3)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC185	Anti-IL1RAP Antibody (11H3)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC185-P	Anti-IL1RAP Antibody (11H3), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC185-A	Anti-IL1RAP Antibody (11H3), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC185-H	Anti-IL1RAP Antibody (11H3), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC185-B	Anti-IL1RAP Antibody (11H3), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-IL1RAP Monoclonal Antibody (11H3)
- Product Description:
  
  The Anti-IL1RAP antibody is a human monoclonal antibody recommended for use in western blot, ELISA, immunohistochemistry, functional assay and other applications. This antibody specifically targets IL1RAP and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Functional Assay
  
  Target:
  
  IL1RAP
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human interleukin 1 receptor accessory protein.
  
  Immunogen:
  
  Human IL1RAP protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  11H3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL1RAP Monoclonal Antibody (11H3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL1RAP

Protein Name

Interleukin-1 receptor accessory protein

Introduction

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.

Alternative Names

IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; interleukin-1 receptor accessory protein; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta

Gene ID

3556

UniProt

Q9NPH3

Cell Line Specificity

Low cancer specificity

Function

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).

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