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Anti-IL18 Monoclonal Antibody (SAIC-24B-4)
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Product Description:The Anti-IL18 antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets IL18 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western blotTarget:IL18Target Species:HumanSpecificity:This antibody reacts with Human IL18.Immunogen:KLH-conjugated peptide from IL-18.Clonality:MonoclonalClone ID:SAIC-24B-4Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL18 Monoclonal Antibody (SAIC-24B-4) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL18
Protein Name
Interleukin-18
Introduction
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm.
Alternative Names
IGIF; IL-18; IL-1g; IL1F4
Gene ID
UniProt
Subcellular Location
Cytoplasm, cytosol
Tissue Specificity
Isoform 2: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.
Cell Line Specificity
Low cancer specificity
Function
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.
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