Anti-IL17C Monoclonal Antibody (4F9)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC380	Anti-IL17C Antibody (4F9)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC380-P	Anti-IL17C Antibody (4F9), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC380-A	Anti-IL17C Antibody (4F9), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC380-H	Anti-IL17C Antibody (4F9), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC380-B	Anti-IL17C Antibody (4F9), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC380

Anti-IL17C Antibody (4F9)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC380-P

Anti-IL17C Antibody (4F9), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC380-A

Anti-IL17C Antibody (4F9), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC380-H

Anti-IL17C Antibody (4F9), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC380-B

Anti-IL17C Antibody (4F9), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-IL17C Monoclonal Antibody (4F9)
- Product Description:
  
  The Anti-IL17C antibody is a human monoclonal antibody recommended for use in ELISA, blocking and other applications. This antibody specifically targets IL17C and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Blocking
  
  Target:
  
  IL17C
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human IL17c (Interleukin 17c).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  4F9
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL17C Monoclonal Antibody (4F9) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL17C

Protein Name

Interleukin-17C

Introduction

The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells.

Alternative Names

CX2; IL-17C

Gene ID

27189

UniProt

Q9P0M4

Subcellular Location

Secreted.

Function

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

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