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Anti-IL15 Monoclonal Antibody (1H12)
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Product Description:The Anti-IL15 antibody is a human monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets IL15 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western BlotTarget:IL15Target Species:HumanSpecificity:This antibody reacts with human IL15.Clonality:MonoclonalClone ID:1H12Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL15 Monoclonal Antibody (1H12) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL15
Protein Name
Interleukin-15
Introduction
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Alternative Names
IL15; interleukin 15; IL-15; interleukin-15
Gene ID
UniProt
Molecule Mass
Cytokines
Tissue Specificity
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Cell Line Specificity
Low cancer specificity
Function
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
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