Anti-IL12B Monoclonal Antibody (Briakinumab)

Subcat	Description	Isotype	Conjugate	Price
ASPC1189	Anti-IL12B Antibody (Briakinumab)	Human IgG1, Lambda	None	$460	Add
ASPC1189-A	Anti-IL12B Antibody (Briakinumab), APC	Human IgG1, Lambda	APC	$980	Add
ASPC1189-B	Anti-IL12B Antibody (Briakinumab), Biotin	Human IgG1, Lambda	Biotin	$680	Add
ASPC1189-H	Anti-IL12B Antibody (Briakinumab), HRP	Human IgG1, Lambda	HRP	$600	Add
ASPC1189-P	Anti-IL12B Antibody (Briakinumab), PE	Human IgG1, Lambda	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1189

Anti-IL12B Antibody (Briakinumab)

Human IgG1, Lambda

None

$460

Add

ASPC1189-A

Anti-IL12B Antibody (Briakinumab), APC

Human IgG1, Lambda

APC

$980

Add

ASPC1189-B

Anti-IL12B Antibody (Briakinumab), Biotin

Human IgG1, Lambda

Biotin

$680

Add

ASPC1189-H

Anti-IL12B Antibody (Briakinumab), HRP

Human IgG1, Lambda

HRP

$600

Add

ASPC1189-P

Anti-IL12B Antibody (Briakinumab), PE

Human IgG1, Lambda

$1,180

Add

Anti-IL12B Monoclonal Antibody (Briakinumab)
- Product Description:
  
  The Anti-IL12B antibody is a human monoclonal antibody recommended for use in blocking and other applications. This antibody specifically targets IL12B and demonstrates reactivity with human.
  
  Applications:
  
  Blocking
  
  Target:
  
  IL12B
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human IL12B.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Briakinumab
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-IL12B Monoclonal Antibody (Briakinumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

IL12B

Protein Name

Interleukin-12 subunit beta

Introduction

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative Names

CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2

Gene ID

3593

UniProt

P29460

Subcellular Location

Secreted.

Cell Line Specificity

Cancer enriched

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

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