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Anti-IL12B Monoclonal Antibody (Antibody 80)
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Product Description:The Anti-IL12B antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, neutralization, inhibition, functional assay and other applications. This antibody specifically targets IL12B and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Neutralization, Inhibition, Functional AssaySource:MouseTarget:IL12BTarget Species:HumanSpecificity:This antibody reacts with Human IL12B.Immunogen:Human IL-12.Clonality:MonoclonalClone ID:Antibody 80Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL12B Monoclonal Antibody (Antibody 80) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL12B
Protein Name
Interleukin-12 subunit beta
Introduction
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Alternative Names
CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2
Gene ID
UniProt
Subcellular Location
Secreted.
Cell Line Specificity
Cancer enriched
Function
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
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