Anti-IDH1/IDH2 Mutant Monoclonal Antibody (MsMab-1)

Anti-IDH1/IDH2 Mutant Monoclonal Antibody (MsMab-1)

Cat No: ASPC1186

Summary
Host Species:
Mouse
Species Reactivity:
Human
Applications:
Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Western Blot
Clone ID:
MsMab-1
Clonality:
Monoclonal

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Product Information
Subcat Description Isotype Antibody Modification Conjugate Size Price Quantity
ASPC1186 Anti-IDH1/IDH2 Mutant Antibody (MsMab-1) Mouse IgG2a, Kappa None $460
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ASPC1186-A Anti-IDH1/IDH2 Mutant Antibody (MsMab-1), APC Mouse IgG2a, Kappa APC $980
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ASPC1186-B Anti-IDH1/IDH2 Mutant Antibody (MsMab-1), Biotin Mouse IgG2a, Kappa Biotin $680
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ASPC1186-H Anti-IDH1/IDH2 Mutant Antibody (MsMab-1), HRP Mouse IgG2a, Kappa HRP $600
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ASPC1186-P Anti-IDH1/IDH2 Mutant Antibody (MsMab-1), PE Mouse IgG2a, Kappa PE $1,180
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Custom Antibody We can also offer conjugation antibodies (Alexa Fluor, Cy, APC, etc.) and other format antibodies (low endotoxin, Fab, scFv, etc.)

  • Anti-IDH1/IDH2 Mutant Monoclonal Antibody (MsMab-1)
    • Product Description:
      The Anti-IDH1/IDH2 Mutant antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets IDH1/IDH2 Mutant and demonstrates reactivity with human.
      Applications:
      Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Western Blot
      Target:
      IDH1/IDH2 Mutant
      Target Species:
      Human
      Specificity:
      This antibody reacts with Human IDH1/IDH2 Mutant.
      Immunogen:
      KLH-conjugated synthetic peptide (IDH1-R132G)
      Clonality:
      Monoclonal
      Clone ID:
      MsMab-1
      Purification:
      The antibody was purified by affinity chromatography.
      Purity:
      >95% as determined by SDS-PAGE
      Aggregation:
      <5% as determined by SEC
      Concentration:
      1 mg/mL
      Form:
      Liquid
      Endotoxin:
      Please contact us for more information.
      Formulation:
      Contact us for custom product formulation.
      Preservative:
      BSA and Azide free.
      Stabilizer:
      None
      Shipping:
      Shipped at 4°C.
      Storage:
      This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
  • Anti-IDH1/IDH2 Mutant Monoclonal Antibody (MsMab-1) Applications
    • Note:
      Optimal dilutions/concentrations should be determined by the end user.
Gene Symbol
IDH1
Protein Name
Isocitrate dehydrogenase [NADP] cytoplasmic
Introduction
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alternative Names
IDH1/2 Mutant (R132/172); IDH1/2 Mutant; IDH1; IDH2
Gene ID
UniProt
Subcellular Location
Cytoplasm, cytosol
Cell Line Specificity
Low cancer specificity
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