Anti-HTRA1 Monoclonal Antibody (3G9)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC531	Anti-HTRA1 Antibody (3G9)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC531-P	Anti-HTRA1 Antibody (3G9), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC531-A	Anti-HTRA1 Antibody (3G9), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC531-H	Anti-HTRA1 Antibody (3G9), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC531-B	Anti-HTRA1 Antibody (3G9), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-HTRA1 Monoclonal Antibody (3G9)
- Product Description:
  
  The Anti-HTRA1 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, functional assay, inhibition and other applications. This antibody specifically targets HTRA1 and demonstrates reactivity with human, mouse.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Inhibition, Western Blot
  
  Target:
  
  HTRA1
  
  Target Species:
  
  Mouse
  
  Specificity:
  
  This antibody reacts with human HTRA1.
  
  Immunogen:
  
  Mouse HTRA1 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  3G9
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-HTRA1 Monoclonal Antibody (3G9) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

HTRA1

Protein Name

Serine protease HTRA1

Introduction

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative Names

HTRA1; HtrA serine peptidase 1; L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; serine protease HTRA1; IGFBP5-protease; protease, serine, 11 (IGF binding); high-temperature requirement A serine peptidase 1

Gene ID

5654

UniProt

Q92743

Related Disease

Macular degeneration, age-related, 7 (ARMD7)

Subcellular Location

Cell membrane

Cell Line Specificity

Low cancer specificity

Function

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

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