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Anti-HSV-1 gB Monoclonal Antibody (Fd79)
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Product Description:The Anti-HSV-1 gB antibody is a mouse monoclonal antibody recommended for use in immunofluorescence, flow cytometry, neutralization and other applications. This antibody specifically targets HSV-1 gB.Applications:Immunofluorescence, Flow Cytometry, NeutralizationTarget:HSV-1 gBSpecificity:This antibody reacts with HSV-1 gB.Immunogen:Herpes simplex virus (HSV).Clonality:MonoclonalClone ID:Fd79Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HSV-1 gB Monoclonal Antibody (Fd79) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
gB
Protein Name
Envelope glycoprotein B
Introduction
Glycoprotein B (gB) of Herpes Simplex Virus type 1 (HSV-1) is a major envelope glycoprotein. It is essential for the virus to enter host cells by mediating the fusion of the viral envelope with the host cell membrane. gB is also a primary target for neutralizing antibodies.
Alternative Names
Herpesvirus glycoprotein B; HSV gB; HSV-1 gB; Envelope glycoprotein B
UniProt
Subcellular Location
Virion membrane
Function
Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
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